Systemic sclerosis - associated interstitial lung disease – proposed recommendations for future randomised clinical trials

نویسندگان

  • Dinesh Khanna
  • Kevin K. Brown
  • Robert Elashoff
  • Daniel E. Furst
  • James R. Seibold
  • Richard M. Silver
  • Donald P. Tashkin
  • Athol U. Wells
  • David Geffen
چکیده

1Division of Rheumatology, 2Biomathematics, 3Pulmonary and Critical Care, Department of Medicine, and 4Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 5Department of Medicine, National Jewish Health, Denver, CO, USA; 6Division of Rheumatology, University of Connecticut Health Center, Farmington, CT, USA; 7Division of Rheumatology, Medical University of South Carolina, Charleston, SC, USA; 8Royal Brompton Hospital and National Heart and Lung Institute, London, U.K. Authorship arranged alphabetically (except for first author). Dinesh Khanna, MD, MS Kevin K. Brown, MD Philip J, Clements, MD, MPH Robert Elashoff, PhD Daniel E. Furst, MD Jonathan Goldin, MD, PhD James R. Seibold, MD Richard M. Silver, MD Donald P. Tashkin, MD Athol U. Wells, MD Please address correspondence to: Dinesh Khanna, MD, MS, David Geffen School of Medicine at UCLA, 90095 Los Angeles, CA, USA. E-mail: [email protected] Received on May 10, 2010; accepted on May 11, 2010. Clin Exp Rheumatol 2010: 28 (Suppl. 58): S55-S62. © Copyright CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 2010.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Systemic sclerosis-associated interstitial lung disease-proposed recommendations for future randomized clinical trials.

Pulmonary disease is the leading cause of morbidity and mortality in patients with systemic sclerosis (SSc). Recent well-designed trials in SSc-associated interstitial lung disease (SSc-ILD) have provided important insights regarding outcome measures and trial design. Recent investigations into the pathogenesis of SSc-ILD have led to a renewed interest in assessing targeted therapies in SSc-ILD...

متن کامل

Interstitial lung disease in connective tissue disorders.

Some of the most pressing challenges associated with interstitial lung disease (ILD) are how best to define, diagnose, and treat connective tissue disease-associated ILD (CTD-ILD)--disorders with potentially substantial morbidity and mortality. In this focused review, we address aspects of prognosis for CTD-ILD and what indices might predict outcome, together with lessons that can be learnt fro...

متن کامل

Management of interstitial lung disease in systemic sclerosis: lessons from SLS and FAST.

Interstitial lung disease (ILD) is a leading cause of death in systemic sclerosis (SSc). Two randomized controlled trials recently demonstrated the modest effects of cyclophosphamide on lung physiology (forced vital capacity) and extrapulmonary outcomes (dyspnea, function, quality of life, and skin thickening). Recommendations can now be made about the short-term management for SSc-ILD. However...

متن کامل

Recent advances in the diagnosis and treatment of interstitial lung disease in systemic sclerosis (scleroderma): a review.

Interstitial lung disease (ILD) in systemic sclerosis (scleroderma) is a rare and potentially lethal and devastating autoimmune disease, and yet the cause of it remains poorly understood. It is associated with tissue fibrosis not only in the lungs, but also other organs like the heart and kidneys. Although ILD can manifest itself in various disease presentations, ILD in systemic sclerosis is pa...

متن کامل

A Case Report of Small Cell Lung Carcinoma in a Patient with Progressive Diffuse Sclerosis

 Connective tissue diseases, including scleroderma, may be associated with an increased risk of lung cancer. The most common type of lung cancer associated with systemic sclerosis is adenocarcinoma or bronchoalveolar carcinoma, and small cell carcinoma is rare. This reports presents a 54-year-old non-smoker woman with a history of scleroderma who was examined due to aggravation of shortness of ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010